Ireland v Wales
Musgrave Park, Cork
Friday, 4 February, 2022		 Referee: Julianne Zussman (RC)
Assistant Referee 1: Maria Beatrice Benvenuti (FIR)
Assistant Referee 2: Maria Giovanna Pacifico (FIR)
TMO: Ian Tempest (RFU)
Scotland v England
Dam Health Stadium, Edinburgh
Friday, 4 February, 2022		 Referee: Benoit Rousselet (FFR)
Assistant Referee 1: Aurelie Groizeleau (FFR)
Assistant Referee 2: Luc Ramos (FFR)
TMO: Eric Gauzins (FFR)
France v Italy
Stade Guy Boniface, Mont de Marsan
Friday 4 February 2022		 Referee: Eoghan Cross (IRFU)
Assistant Referee 1: Chris Busby (IRFU)
Assistant Referee 2: Aled Evans (WRU)
TMO: Olly Hodges (IRFU)
Italy v England
Stadio Comunale di Monigo, Treviso
Friday, 11 February, 2022		 Referee: Aurelie Groizeleau (FFR)
Assistant Referee 1: Benoit Rousselet (FFR)
Assistant Referee 2: Luc Ramos (FFR)
TMO: Eric Gauzins (FFR)
Wales v Scotland
Parc Eirias, Colwyn Bay
Friday, 11 February, 2022		 Referee: Sara Cox (RFU)
Assistant Referee 1: Nikki O'Donnell (RFU)
Assistant Referee 2: Doriane Domenjo (FFR)
TMO: Claire Hodnett (RFU)
France v Ireland
Stade Maurice David, Aix-en-Provence
Friday, 11 February, 2022		 Referee: Hollie Davidson (SRU)
Assistant Referee 1: Ben Blain (SRU)
Assistant Referee 2: Tual Trainini (FFR)
TMO: Sam Grove White (SRU)
England v Wales
Castle Park, Doncaster
Friday, 25 February, 2022		 Referee: Joy Neville (IRFU)
Assistant Referee 1: Aurelie Groizeleau (FFR)
Assistant Referee 2: Doriane Domenjo (FFR)
TMO: Olly Hodges (RFU)
Scotland v France
Dam Health Stadium, Edinburgh
Friday, 25 February, 2022		 Referee: Clara Munarini (FIR)
Assistant Referee 1: Nikki O'Donnell (RFU)
Assistant Referee 2: Maria Giovanna Pacifico (FIR)
TMO: Claire Hodnett (RFU)
Ireland v Italy
Musgrave Park, Cork
Friday, 25 February, 2022		 Referee: Aled Evans (WRU)
Assistant Referee 1: Luc Ramos (FFR)
Assistant Referee 2: Benoit Rousselet (FFR)
TMO: Ben Whitehouse (WRU)
Wales v France
Parc Eirias, Colwyn Bay
Thursday, 10 March, 2022		 Referee: Shota Tevadze (GRU)
Assistant Referee 1: Saba Abulashvili (GRU)
Assistant Referee 2: Eoghan Cross (IRFU)
TMO: Ian Tempest (RFU)
Italy v Scotland
Stadio Comunale di Monigo, Treviso
Friday, 11 March, 2022		 Referee: Aimee Barrett-Theron (SARU)
Assistant Referee 1: Adriaan Jacobs (SARU)
Assistant Referee 2: Precious Pazani (ZIM)
TMO: Olly Hodges (IRFU)
England v Ireland
StoneX Stadium, London
Saturday, 12 March, 2022		 Referee: Damian Schneider (UAR)
Assistant Referee 1: Aled Evans (WRU)
Assistant Referee 2: Federico Vedovelli (FIR)
TMO: Matteo Liperini (FIR)
Wales v Italy
Parc Eirias, Colwyn Bay
Sunday, 20 March, 2022		 Referee: Damian Schneider (UAR)
Assistant Referee 1: Benoit Rousselet (FFR)
Assistant Referee 2: Luc Ramos (FFR)
TMO: Eric Gauzins (FFR)
Ireland v Scotland
Musgrave Park, Cork
Sunday, 20 March, 2022		 Referee: Federico Vedovelli (FIR)
Assistant Referee 1: Shota Tevadze (GRU)
Assistant Referee 2: Saba Abulashvili (GRU)
TMO: Matteo Liperini (FIR)
France v England
Stade Aime Giral, Perpignan
Sunday, 20 March, 2022		 Referee: Adriaan Jacobs (SARU)
Assistant Referee 1: Aimee Barrett-Theron (SARU)
Assistant Referee 2: Precious Pazani (ZIM)
TMO: Olly Hodges (IRFU)