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Real Madrid vs. Liverpool Odds, Picks, Predictions: Round of 16 Giant Killer

Emanuel Rosu

Last Updated: February 21, 2023 8:30 AM EST • 2 min 5 sec read.

Darwin Nunez of Liverpool celebrates a goal 0-1 between Newcastle United and Liverpool on Feb. 18. Will the Reds emerge in our Real Madrid vs. Liverpool picks?
Darwin Nunez of Liverpool celebrates a goal 0-1 between Newcastle United and Liverpool on Feb. 18. Will the Reds emerge in our Real Madrid vs. Liverpool picks? Photo Malcolm Mackenzie / ProSportsImages / DPPI

After Paris Saint-Germain versus Bayern last week, the Champions League Round of 16 phase continues with another shock, as last year’s finalists face off for a seat in this season’s quarter finals. Here are our Real Madrid vs. Liverpool picks and predictions based on the best Champions League odds.

It’s been all noise in Liverpool this season. Manager Jurgen Klopp has been criticized heavily by the media and part of the fanbase has blamed his tactical choices that left the team mid-table in the Premier League.

Real Madrid are not drinking champagne from the Champions League trophy either right now. Despite having just triumphed in the Club World Cup, they sit eight points behind FC Barcelona in the Spanish La Liga standings and are likely to lose the title. This spring’s Champions League run might be their best chance of saving the season.

This double-legged clash between Liverpool and Real Madrid surely promises to set the headlines across the continent.

Here is our best Real Madrid vs. Liverpool Champions League pick (odds via ; pick confidence based on a 1-to-5-star scale).

Check out our Champions League odds.

Real Madrid vs. Liverpool pick

Liverpool to score first vs. Real Madrid (-122 via BetMGM) ⭐⭐⭐⭐⭐

If there’s anything that defines Liverpool under Klopp, then it has to be their enthusiasm and belief. In the past, Liverpool have been electric after looking lost in the dark, as the team found resources in the most difficult of times. That’s what they need right now to turn their season around and that’s what Klopp is best at. He injects his team with self-belief and mental strength in an unrivalled way. Even if Liverpool end up leaving the Champions League early this season, it won’t be without a proper fight.

And Real Madrid manager Carlo Ancelotti knows that. Liverpool will look to apply pressure on Real immediately. This strategy worked in the past on numerous occasions and will probably continue to prove itself efficient. Even though opponents know what’s coming their way, they just can’t stop the Red fury. Liverpool are the big favorites to hit the net first in this clash. At -122 via BetMGM, the return is more than decent.

Check out our Champions League Odds and Best Bets

Real Madrid vs. Liverpool best odds

BetMGM (-122)

DraftKingsFanDuelBetMGMPointsBet
Liverpool -130Liverpool -130Liverpool -122Liverpool -130
Real +105Real +105Real +110Real +115

At -122, BetMGM offers the best return for Liverpool to score the first goal of the match. DraftKings, FanDuel, and PointsBet all have the hosts at Anfield at -130. Real scoring first varies between +105 and +115, with PointsBet offering the best odds.

Real Madrid vs. Liverpool game info

  • Date: Tuesday, Feb. 21, 3 p.m. ET
  • TV: fuboTV, Paramount+, CBS Sports
  • Location: Anfield Road, Liverpool, England
  • Weather: 51 degrees, 7% chance of precipitation, 8-mph winds

Liverpool vs. Real Madrid pick made 2/20/2022 at 4:50 p.m. ET.

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Written By:
Emanuel Rosu
Emanuel Rosu has freelanced as a soccer specialist for the BBC, The Guardian, FourFourTwo, Goal, and the New York Times. He's part of the "Ballon d'Or" jury, representing Romania in the vote that rewards the best soccer player in the world each year. He is based in Bucharest, Romania.