NFL Week 8 Odds & Betting Lines: Spread, Moneyline, Over/Under for All 16 Games

The NFL odds for Week 8 are out, and we have a full 16-game slate with no teams on bye. Our best NFL betting sites have been busy making moves all week, and now we're ready for some action tonight.

• The week opened with a battle between the surprise Super Bowl odds contender Minnesota Vikings and the Los Angeles Rams, with the Vikes favored by the Thursday Night Football odds. The Rams pulled off the upset in the return of wideouts Cooper Kupp and Puka Nacua.
• Sleep in! Rejoice! No early international games (don't get too used to that, they're back in Week 9)
• The Sunday Night Football odds have the San Francisco 49ers as favorites over the visiting Dallas Cowboys (8:20 p.m. ET, NBC/Peacock)
• The Monday Night Football odds feature just a single game, with the Pittsburgh Steelers hosting the New York Giants (8:15 p.m. ET, ESPN/ABC/ESPN+)

NFL Week 8 odd and lines

There's an advantage in getting to these NFL odds early and trying to beat any line movement when betting on NFL markets. The closer you wait until Sunday to make your NFL picks, the more difficult it becomes to identify edges and secure the best price on an outcome.

That's why it's important to start monitoring the NFL opening odds each week as soon as possible. A proactive approach will contribute to your long-term success.

Best NFL Week 8 spreads

Odds via DraftKings

• Division games pepper the schedule: Falcons-Bucs (NFC South), Colts-Texans (AFC South), Ravens-Browns (AFC North), Jets-Patriots (AFC East), Chiefs-Raiders (AFC West)
• We might not get the showdown between Offensive Rookie of the Year odds favorite Jayden Daniels and his nearest competitor (Caleb Williams) square off when the Bears and Commanders clash. Daniels suffered a rib injury on Sunday and is considered "week-to-week," although the Commanders are reportedly hopeful he can play Sunday
• Speaking of injuries, yikes. The Bucs swung from 1.5-point favorites to 2.5-point 'dogs after losing Mike Evans and Chris Godwin on Monday Night Football, while the 49ers have gone from 7-point favorites to 4-point favorites in the wake of Brandon Aiyuk suffering a season-ending injury, George Kittle dealing with a foot injury, and Deebo Samuel contracting pneumonia
• ATS leaders heading into Week 8: Colts (6-1); Lions, Vikings, Chiefs (5-1); Commanders (5-1-1)
• ATS losers heading into Week 8: Panthers (1-6); Patriots (1-5-1); Titans, Dolphins, Rams (1-5)

Best NFL Week 8 moneylines

Odds via FanDuel

Some of these games have pretty sizable storylines surrounding them that could cause major shifts before kickoff:

• Will Doug Pederson remain the Jaguars head coach with the team off to a rocky start? They beat the Pats, that should buy him an extra week at least.
• How will the Bills look with Amari Cooper? How will the Jets look with Davante Adams? Both receivers had minimal impacts, and neither moneyline has moved in the wake of Week 7
• Will Tua Tagovailoa be able to return for the Dolphins? We're still waiting on word here, but it seems like he could be back. Oddsmakers agree, as the Dolphins continue to pull away as favorites.
• How will the Steelers perform with Russell Wilson instead of Justin Fields under center? Pittsburgh had its highest offensive output of the season with Russ, who will surely be getting the nod again, and it's picked up major steam going from -198 to -295 in early betting

Best NFL Week 8 Over/Unders

Odds via bet365

• Monday Night Football. Get excited. Island Game. All eyes. Lowest total of the week, just 36.5 points between the Giants and Steelers.
• Our highest openers (Eagles-Bengals, 49.5; Cowboys-49ers, 49) have bucked the trend of being bet up to 50 early, with both games losing steam
• Over leaders heading into Week 8: Ravens (6-1); Bucs, Seahawks, Panthers, Saints, Commanders (5-2)
• Under leaders heading into Week 8: Giants (1-6); Chargers, Dolphins (1-5)

NFL betting odds pages

Here are our best NFL betting sites:

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• bet365 Bonus Code: SBRBONUS | Read our bet365 Review
• FanDuel Promo Code | Read our FanDuel Review
• DraftKings Promo Code | Read our DraftKings Review

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• Best Sports Betting Sites | Best Sportsbook Promos (U.S. only)