NFL Week 6 Odds & Betting Lines: Spread, Moneyline, Over/Under for All 14 Games

The NFL odds for Week 6 are out and we've had plenty of movement from our best NFL betting sites based on Week 5 results.

• The Thursday Night Football odds favorite San Francisco 49ers opened the week with a 36-24 victory over the Seattle Seahawks
• London games continue with Offensive Rookie of the Year odds contender Caleb Williams and the Chicago Bears squaring off with the Jacksonville Jaguars (9:30 a.m. ET, NFL Net)
• The Sunday Night Football odds have the Cincinnati Bengals as comfortable favorites over the New York Giants (8:20 p.m. ET, NBC/Peacock); the Buffalo Bills are short Monday Night Football odds favorites when they visit the New York Jets (8:15 p.m. ET, ESPN)
• The Super Bowl odds favorite Kansas City Chiefs, Los Angeles Rams, Miami Dolphins, and Minnesota Vikings are on bye

Let's take a closer look at all the other opening odds to help with your NFL Week 6 early picks.

NFL Week 6 odds & lines

When betting on NFL markets, there's an advantage in getting to the early and trying to beat any line movements. The closer you wait until Sunday to make your NFL picks, the more difficult it becomes to identify edges and secure the best price on the outcome you wish to bet on.

That's why it's important to start monitoring the NFL opening odds each week as soon as possible. This proactive approach will contribute to your long-term success in your sports betting endeavors.

Best NFL Week 6 spreads

Odds via DraftKings

• Eight games remain with the road team lined as the favorite heading into the weekend
• The Ravens, Texans, and Eagles opened as 6.5-point favorites, the largest opener of the week, but Philadelphia has pulled away to -9.5
• New Orleans is the biggest mover of the week, flipping from a 3-point favorite to a 3.5-point underdog after a subpar performance on Monday Night Football where QB Derek Carr suffered an injury that may keep him sidelined
• Key divisional matches include the 49ers vs. Seahawks (San Francisco won on TNF), Bucs vs. Saints, and Bills vs. Jets

Best NFL Week 6 moneylines

Odds via FanDuel

• We recommended if you liked home 'dogs to wait until Week 5 wraps up to pounce on some of these lines, suggesting it would not be shocking to see lines lengthen for the Seahawks, Broncos, Panthers, and Jets -- and all four lengthened.
• The Ravens (-300), Eagles (-480), Texans (-335), Falcons (-270), and Packers (-250) are all prohibitive betting favorites

Best NFL Week 6 Over/Unders

Odds via bet365

• The week opened with an Over, finishing with 60 points on a total of 48.5
• The Chargers, Broncos, Steelers, and Raiders have their Week 6 games lined under 40 points after playing to the Under in 13 of 19 combined game
• The Patriots anemic offense resulted in the biggest early drop in the week, going from 41.5 to 38 in their game with the Texans
• The Falcons looking sharp in a big division game resulted in a big bump, jumping from 44.5 to 47
• The Bengals-Giants opened at 46.5 points before jumping to 48 points, although the Giants were one of two teams that have logged four Unders through four weeks before snapping the skid with their first Over last week

NFL betting odds pages

Here are our best NFL betting sites:

• Caesars Promo Code: SBRBONUSDYW | Read our Caesars Review
• BetMGM Bonus Code: SBRBONUS | Read our BetMGM Review
• bet365 Bonus Code: SBRBONUS | Read our bet365 Review
• FanDuel Promo Code | Read our FanDuel Review
• DraftKings Promo Code | Read our DraftKings Review

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Related pages

• Best Sports Betting Sites | Best Sportsbook Promos (U.S. only)