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Week 2 NFL Parlay Predictions, Odds - Giants Get Right in Arizona

Connor Cooper

Last Updated: September 17, 2023 8:46 AM EDT • 4 min 5 sec read.

In Week 1 against the Dallas Cowboys, the Giants had a rough start, but they have an opportunity to turn things around on Sunday as we analyze their matchup in our NFL parlay predictions for Week 2, utilizing the top NFL odds from the best sports betting apps.

The New York Giants had a disappointing start to their 2023 season when they suffered a 40-0 loss at home to Dallas, coming off a surprise playoff appearance in 2022. New York found themselves trailing 26-0 before the midway point of the second quarter, and the Giants committed five fumbles while allowing seven sacks in this dismal performance.

Still, the Giants are favored by more than a field goal for their Week 2 visit to the Arizona Cardinals, a team that nearly pulled off an upset as touchdown underdogs during Week 1 in Washington. Can New York bounce back, or will Arizona send the Giants tumbling to an 0-2 start?

For more, check out all of our NFL Week 2 predictions and NFL upset picks.

Here are our best NFL parlay predictions (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale)

Best NFL Week 2 parlay predictions 

Seahawks-Lions Over 47 () ⭐⭐⭐⭐

This is a classic bounce-back spot for the Seahawks after they essentially no-showed in the second half of their season opener versus the Rams, surrendering 23 unanswered points in a 30-13 loss at home. The players are saying all the right things, including star receiver DK Metcalf, who told the that the Rams simply played harder than his Seahawks. 

However, if Seattle is going to bounce back, the team will need to put up points. Detroit’s offense wasn’t that impressive on Kansas City’s grass field in Week 1, scoring just 14 points (one of the Lions’ three scores came on an interception return). But the Lions are much more dangerous on the turf of Ford Field, where they’ve put up 25-plus points in 11 of their last 12 contests. They'll also enjoy the luxury of a few extra days to prepare after opening the season last Thursday.

Injuries oalong Seattle’s offensive line led to early action on the Under, dropping this total from 51 to 47. There’s been an average of 91.5 points scored in two meetings between these teams over the last two years, so I’ll happily be part of the buyback on the Over.

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New York Giants ML () ⭐⭐⭐⭐⭐

There aren’t many worse ways to open a season than getting dominated 40-0 at home by a division rival on national television. But as bad as the Giants were Sunday night against Dallas, we do need to take that outcome with a grain of salt. New York self-destructed in the first quarter while allowing a blocked field-goal return for a TD and a pick-6, putting the G-Men in an early 16-0 hole that required Daniel Jones to throw during almost every play against Dallas’ ferocious pass rush.

A visit to Arizona is the perfect get-right spot for a Giants team that's chomping at the bit to prove its 2022 playoff appearance was no fluke. The Cardinals entered the campaign as the favorite to be the league's worst squad, and keeping it close against Washington in a 20-16 loss during Week 1 shouldn’t change that outlook. Arizona gained only 13 first downs, but the team managed to stay in the game thanks to three Commanders turnovers and Washington scoring TDs on just two of five red-zone trips.

The Cards are also getting one of the weakest home-field advantages in the league. They've gone 4-10 against the spread in their last 14 matchups at home and lost eight straight as a home dog. If you put the Week 1 results out of your mind, the Giants' moneyline at -250 or better looks as close as you can get to a free square on your NFL parlay bingo card.

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New York Jets first-half spread +6 () ⭐⭐⭐

New York’s other team suffered an even bigger gut punch in Week 1, losing Aaron Rodgers for the season after just four plays. However, unlike the Giants, the Jets showed a ton of resilience, getting off the mat and rallying from a 13-3 halftime deficit to shock the Bills in overtime.

Zach Wilson was serviceable in relief of Rodgers, leading the Jets to three second-half scoring drives. But the bigger key was a New York defense that sacked Josh Allen five times while forcing four turnovers. That unit can keep the Jets in any game, and Dallas may be a bit overvalued after a 40-0 Week 1 rout of the Giants.

The Cowboys’ first two touchdowns of that outing came on special teams and defense, and Dallas finished the game with just 18 first downs and 265 total yards of offense.

NFL Week 2 parlay:

Week 2 NFL parlay picks made Friday, September 15 at 10:45 a.m. ET

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Written By:
Connor Cooper
Connor Cooper has written about sports in various capacities for more than 20 years, including as a newspaper reporter, sports handicapper, and betting analyst. He originates hockey plays every day throughout the NHL season, regularly bets his own opinions on NFL and college football, and relies on handicappers he trusts to find daily action in basketball, baseball, soccer, tennis, and golf. A diehard Maple Leafs and Blue Jays fan growing up in the Toronto area, Connor quickly shed all his allegiances once he realized that making money betting on sports was much more fun than cheering for his favorite team. Connor won’t hesitate to bet on — or against — anybody if that’s where the value lies. In addition to analyzing recent and season-long statistics, Connor always looks to account for the human element when breaking down games, weighing situational and motivational factors into his handicapping process. He's also a big believer in finding creative ways to generate more value, constantly scouring BetMGM, Caesar, FanDuel, and other regulated sportsbooks' derivative markets such as team totals, alternate lines, and player props.