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Green Bay Packers wide receiver Romeo Doubs celebrates with Green Bay Packers quarterback Jordan Love as we examine the latest NFL Week 16 odds and predictions.
Green Bay Packers wide receiver Romeo Doubs (87) celebrates with Green Bay Packers quarterback Jordan Love (10) following a touchdown pass. Photo by Joe Nicholson / Imagn Images.

Just three weeks remain in the NFL regular season as we turn our attention to the NFL Week 16 odds and predictions for the top games this week.

The action starts with a Thursday Night Football odds showdown between AFC West contenders, as the Denver Broncos take on the home favorite Los Angeles Chargers for an 8:15 p.m. ET kickoff at SoFi Stadium (Prime Video).

We'll be treated to two more showdowns between Super Bowl odds hopefuls on Saturday, when the Kansas City Chiefs host the Houston Texans at 1 p.m. ET (NBC) and the Pittsburgh Steelers travel a familiar road to face the Baltimore Ravens at 4:30 p.m. ET (FOX).

Sunday features 12 games in total, capped off by the Dallas Cowboys playing the role of home underdogs by the Sunday Night Football odds. That one kicks off at 8:20 p.m. ET at NBC, while the Monday Night Football odds clash between the New Orleans Saints and Green Bay Packers is set for 8:15 p.m. ET (ESPN).

NFL picks & predictions Week 16

  • Broncos vs. Chargers early picks (TNF)
    • Broncos vs. Chargers prediction
    • Broncos vs. Chargers player props
    • Broncos vs. Chargers parlay
    • Bo Nix player props
    • Justin Herbert player props
    • Anytime touchdown scorer predictions for TNF
    • First touchdown scorer predictions for TNF
  • Texans vs. Chiefs early picks (Saturday)
    • Texans vs. Chiefs prediction
    • Texans vs. Chiefs player props
    • Texans vs. Chiefs parlay
  • Steelers vs. Ravens early picks (Saturday)
    • Steelers vs. Ravens prediction
    • Steelers vs. Ravens player props
    • Steelers vs. Ravens parlay
  • Lions vs. Bears prediction
    • Lions vs. Bears player props
  • Eagles vs. Commanders prediction
    • Eagles vs. Commanders player props
  • 49ers vs. Dolphins player props
  • Buccaneers vs. Cowboys early picks (SNF)
    • Buccaneers vs. Cowboys prediction
    • Buccaneers vs. Cowboys player props
    • Buccaneers vs. Cowboys parlay
    • Baker Mayfield player props
    • Anytime touchdown scorer predictions for SNF
    • First touchdown scorer predictions for SNF
  • Saints vs. Packers early picks (MNF)
    • Saints vs. Packers prediction
    • Saints vs. Packers player props

Don't miss the rest of our Week 16 NFL picks. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

NFL odds & predictions for Thursday Night Football

NFL odds via our best NFL betting sites. Follow the latest NFL scores for line history and matchup info.

Broncos vs. Chargers odds

  • When: Thursday, Dec. 19 - 8:15 p.m. ET
  • Where: SoFi Stadium (Inglewood, Calif.)
  • How to watch: Prime Video

NFL odds & predictions for Saturday

Texans vs. Chiefs odds

  • When: Saturday, Dec. 21 - 1 p.m. ET
  • Where: GEHA Field at Arrowhead Stadium (Kansas City, Mo.)
  • How to watch: NBC

Steelers vs. Ravens odds

  • When: Saturday, Dec. 21 - 4:30 p.m. ET
  • Where: M&T Bank Stadium (Baltimore)
  • How to watch: FOX

NFL odds & predictions for Sunday

Lions vs. Bears odds

  • When: Sunday, Dec. 22 - 1 p.m. ET
  • Where: Soldier Field (Chicago)
  • How to watch: FOX

Giants vs. Falcons odds

  • When: Sunday, Dec. 22 - 1 p.m. ET
  • Where: Mercedes-Benz Stadium (Atlanta)
  • How to watch: FOX

Rams vs. Jets odds

  • When: Sunday, Dec. 22 - 1 p.m. ET
  • Where: MetLife Stadium (East Rutherford, N.J.)
  • How to watch: CBS

Titans vs. Colts odds

  • When: Sunday, Dec. 22 - 1 p.m. ET
  • Where: Lucas Oil Stadium (Indianapolis)
  • How to watch: CBS

Cardinals vs. Panthers odds

  • When: Sunday, Dec. 22 - 1 p.m. ET
  • Where: Bank of America Stadium (Charlotte, N.C.)
  • How to watch: FOX

Browns vs. Bengals odds

  • When: Sunday, Dec. 22 - 1 p.m. ET
  • Where: Paycor Stadium (Cincinnati)
  • How to watch: CBS

Eagles vs. Commanders odds

  • When: Sunday, Dec. 22 - 1 p.m. ET
  • Where: Northwest Stadium (Landover, Md.)
  • How to watch: FOX

Vikings vs. Seahawks odds

  • When: Sunday, Dec. 22 - 4:05 p.m. ET
  • Where: Lumen Field (Seattle)
  • How to watch: FOX

Jaguars vs. Raiders odds

  • When: Sunday, Dec. 22 - 4:25 p.m. ET
  • Where: Allegiant Stadium (Las Vegas)
  • How to watch: CBS

49ers vs. Dolphins odds

  • When: Sunday, Dec. 22 - 4:25 p.m. ET
  • Where: Hard Rock Stadium (Miami Gardens, Fla.)
  • How to watch: CBS

Patriots vs. Bills odds

  • When: Sunday, Dec. 22 - 4:25 p.m. ET
  • Where: Highmark Stadium (Orchard Park, N.Y.)
  • How to watch: CBS

NFL odds & predictions for Sunday Night Football

Buccaneers vs. Cowboys odds

  • When: Sunday, Dec. 22 - 8:20 p.m. ET
  • Where: AT&T Stadium (Arlington, Texas)
  • How to watch: NBC

NFL odds & predictions for Monday Night Football

Saints vs. Packers odds

  • When: Monday, Dec. 23 - 8:15 p.m. ET
  • Where: Lambeau Field (Green Bay, Wis.)
  • How to watch: ABC / ESPN

NFL picks roundup: Week 16

  • NFL Week 16 ATS picks
  • NFL Week 16 upset picks
  • NFL Week 16 best bets
  • NFL Week 16 player props
  • NFL Week 16 touchdown parlay
  • NFL Week 16 anytime touchdown scorer predictions

NFL betting odds pages

Here are our best NFL betting sites:

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