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San Francisco 49ers running back Christian McCaffrey rushes the ball against the Seattle Seahawks, and he headlines our NFL Week 13 player prop bets.
San Francisco 49ers running back Christian McCaffrey rushes the ball against the Seattle Seahawks. Photo by David Gonzales via Imagn Images.

Three NFL games are already in the books, but the weekend slate still provides 13 more opportunities from which to make the best NFL Week 13 player prop picks.

  • Saquon Barkley’s NFL MVP odds skyrocketed thanks to his record-setting performance last week
  • Five of the remaining 13 games this week are divisional matchups
  • The Philadelphia Eagles vs. Baltimore Ravens matchup is the only game with a projected total in the 50s

We explore those stories and more as part of our NFL Week 13 predictions.

NFL player prop bets for Week 13

NFL odds subject to change. Track the NFL scores for the latest line movement and matchup info.

  • Aaron Rodgers Under 219.5 passing yards () vs. Seahawks ⭐⭐⭐
  • Drake London Under 67.5 receiving yards (-110 via bet365) vs. Chargers ⭐⭐⭐⭐⭐
  • Christian McCaffrey anytime touchdown scorer () at Bills ⭐⭐⭐
  • Baker Mayfield Over 1.5 passing touchdowns (-120 via bet365) vs. Panthers ⭐⭐⭐⭐⭐

NFL picks made Friday. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Best NFL player prop bets this week

Aaron Rodgers Under 219.5 passing yards ⭐⭐⭐

Best odds: -110 via bet365 | Implied probability: 52.38%

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With Aaron Rodgers a couple of days away from turning 41, he is one of the least mobile starting quarterbacks left in the league. He has been under relentless pressure all season and now faces one of the best pass rushes in the league.

With a standard pass rush, the Seahawks generate pressure 34% of the time (ranks second), allow 5.4 yards per dropback (third), and have 25 sacks (tied for fifth).

Seattle is coming off a game in which it pressured Matthew Stafford on 40% of his dropbacks, which was its fifth game this season with a pressure rate above 35%.

This is only a three-star play as Rodgers may need to throw more if running back Breece Hall is unable to play. I am making this wager at bet365, the only one of our best sports betting sites offering less than -115 juice to back the Under.

Drake London Under 67.5 receiving yards ⭐⭐⭐⭐⭐

Best odds: -110 via bet365 | Implied probability: 52.38%

Drake London faces a Chargers defense that has allowed the second-most yards and most touchdowns to wide receivers since Week 8. 

Despite the plus-matchup, I am down on London, who was a limited participant in Thursday’s practice with a hip injury, and I'm higher on teammate Darnell Mooney given L.A.’s defensive tendencies.

Los Angeles uses zone coverage at the third-highest rate. Mooney is top-12 in yards in the NFL against zone coverage. 

The Chargers also play split-safety coverage at the second-highest rate in the league, and Mooney has the highest passer rating when targeted against that coverage. 

I would not put anyone off Mooney’s Overs when they become available, but in the meantime I'm backing the Under on London’s receiving yards. 

bet365 is the only one of our best sports betting apps offering the Under of 67.5 (others are as low as 65.5) while charging the standard -110 juice.

Christian McCaffrey anytime touchdown scorer ⭐⭐⭐⭐⭐

Best odds: -119 via Caesars | Implied probability: 54.34%

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Christian McCaffrey hasn't scored a touchdown in three straight games for the first time since 2021. 

I am taking advantage of McCaffrey’s much longer touchdown odds as a result, especially since he's coming off being held to fewer than 90 scrimmage yards for the first time in the last 13 games. 

From Weeks 5 to 10, prior to their game against Kansas City, the Bills defense ranked 19th or worse in missed tackle rate and yards before contact per attempt. 

Early weather reports suggest there  could be six inches of snow and 30-mph wind gusts in Buffalo on Sunday night, which sets up to be more of a ground game than a passing game.

Caesars has slightly better odds than DraftKings, which offers -125 odds (carrying a 55.56% implied probability) for McCaffrey to find the endzone.  

Baker Mayfield Over 1.5 passing touchdowns ⭐⭐⭐⭐⭐

Best odds: -120 via bet365 | Implied probability: 54.55%

Baker Mayfield is one of four quarterbacks (Joe Burrow, Lamar Jackson, and Jordan Love are the others) averaging two or more touchdown passes per game this season.

Entering last week’s game against the Chiefs, the Panthers' defense ranked in the bottom 12 of the league in passer rating and CPOE (completion percentage over expectancy) allowed since Week 6. 

Mayfield has been a touchdown-throwing machine, leading the NFL in touchdown passes (52) in regular-season starts since joining the Buccaneers. 

This is our most confident five-star play, and we are making it at bet365, as all of the other best sportsbooks charge -125 in juice or higher to back the Over.

Through bet365’s -120 odds, a $10 winning wager would pay out $18.33.

NFL betting odds pages

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