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Panthers vs. Giants Picks, Predictions NFL Week 2: Surprising G-Men Host Carolina as Slim Favorites

Daniel Coyle

Last Updated: September 20, 2022 11:01 AM EDT • 2 min 14 sec read.

The New York Giants pulled one of the many upsets around the NFL last week by dethroning the AFC South champion Tennessee Titans. Here are our top picks for Week 2 as the Giants host the Carolina Panthers.

The Giants snapped a six-game losing skid that dated back through the end of last season with last week's surprising win as underdogs in head coach Brian Daboll's debut. They seek back-to-back victories for the first time since midway through the 2020 campaign.

The Panthers suffered a narrow loss to the Cleveland Browns in their 2022 home opener. The loss spoiled QB Baker Mayfield's debut with his new team, but he still managed to rush for a score.

Here are our top Panthers-Giants NFL picks for Week 2 (odds via  PointsBet and FanDuel Sportsbook; pick confidence based on a 1-to-5-star scale).

Panthers vs. Giants Game Info

Date: Sunday Sept. 18, 1 p.m. ET
TV: FOX
Location: MetLife Stadium, East Rutherford, NJ
Weather: 82 degrees, 10% chance of precipitation, 11-mph winds 

Panthers vs. Giants Odds Analysis

Despite the Week 1 results, this matchup is now a pick'em after the Giants opened as 1.5-point favorites. The Panthers have received 65% of the bets and 67% of the handle on the spread.

The Over/Under was raised from 42.5 to 43.5 despite 61% of the tickets on the Over accounting for just 40% of the handle.

Panthers vs. Giants Picks

  • Spread: Giants -1.5 (-112 via FanDuel) ★★★
  • Over/Under: Over 43.5 (-107 via PointsBet) ★★★
  • Prop: Saquon Barkley vs. Christian McCaffrey rushing yards: Barkley (-125 via DraftKings) ★★★★

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Panthers vs. Giants ATS Pick

Giants -1.5 (-112) ★★★

Considering the dismal form that both teams displayed to close out last season, it's a tough matchup for NFL bettors to get excited about. However, it's impossible to overlook the huge lift rookie head coach Brian Daboll’s daring play calling gave his team in last week’s win over Tennessee. 

Unlike the Panthers, who failed to ward off a late rally by quarterback Baker Mayfield’s former Cleveland teammates in last week’s 26-24 loss, the Giants rose to the occasion against the AFC’s top-seeded team from 2021. The Giants' impressive second-half comeback in Week 1 would have been unthinkable a year ago.

Check out the latest comprehensive and most trusted Sportsbook Reviews by SBR.

Panthers vs. Giants O/U Pick

Over 43.5 (-107) ★★★

Injuries to the Giants' secondary should allow Mayfield to enjoy more success than he did in last week’s grudge match against the Browns. However, Carolina's defense will have its hands full against a New York ground game that steamrolled the Titans for 238 yards last weekend. 

Panthers vs. Giants Prop Pick

Barkley to have more rushing yards than McCaffrey (-125) ★★★★

Giants running back Saquon Barkley is energized after racking up 164 rushing yards, a touchdown, and the game-winning two-point conversion in last weekend’s win.

Conversely, the jury is still out on Panthers running back Christian McCaffrey’s fitness after he was limited to just 33 rushing yards on 10 carries last week. He topped 60 yards just once in his final five outings last season.

Where to Bet on Panthers vs. Giants Picks

Here are our top-rated sportsbooks:

SEE ALSO: All picks, odds, and sports betting news. Be sure to check out 520ccc.com’s community forums and betting tools.

Panthers-Giants picks made 9/15/2022 at 4:23 p.m. ET

Written By:
Daniel Coyle
An award-winning writer based in Montreal, Quebec, Daniel Coyle has covered sports and sports betting for major mainstream and online publications for over two decades. A passionate hockey fan, Daniel has covered a wide array of major sports leagues including the NHL, NFL, NBA, UFC, Formula 1, and US college sports. Daniel has also told the stories of Indigenous athletes from across Canada, and the important role sports play in First Nations communities.