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Lions vs. 49ers Parlay Picks & Predictions: MNF SGP Odds

Brenden Schaeffer

Last Updated: December 30, 2024 1:01 PM EST • 2 min 57 sec read.

San Francisco 49ers tight end George Kittle runs with the ball after a catch against the Miami Dolphins, and we offer our top Lions vs. 49ers parlay.
San Francisco 49ers tight end George Kittle runs with the ball after a catch against the Miami Dolphins. Photo by Jasen Vinlove via Imagn Images.

The San Francisco 49ers opened the campaign as one of the Super Bowl odds favorites, but they're simply playing for pride now in this home game against the juggernaut Detroit Lions.

Our Lions vs. 49ers MNF parlay based on our best Monday Night Football odds believes San Francisco's passing game may have an advantage in the last game of 2024.

The Lions enter this road contest at Levi's Stadium as -3.5 favorites, with the action getting underway at 8:15 p.m. ET (ESPN).

We have a tasty +750 SGP as part of our NFL Week 17 predictions.

Lions vs. 49ers parlay predictions: Monday Night Football

NFL picks based on the odds from our best NFL betting sites. Odds subject to change.

  • Amon-Ra St. Brown Under 6.5 receptions (-110) ⭐⭐⭐⭐
  • Brock Purdy Over 255.5 passing yards (-115) ⭐⭐⭐⭐
  • George Kittle Under 68.5 receiving yards (-120) ⭐⭐⭐⭐

Combined odds: | Implied probability: 11.76%

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SGP predictions for Lions vs. 49ers

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Amon-Ra St. Brown Under 6.5 receptions (-110) ⭐⭐⭐⭐

Although Dan Campbell’s coaching mentality likely won’t permit him to rest his starters Monday night, we’re still being cautious with Lions Overs in this matchup.

Even under straight-up circumstances, the receptions target for Amon-Ra St. Brown would feel lofty against a San Francisco defense that limits the wide receiver position effectively.

  • The 49ers allow just 10.27 receptions per game wide receivers (second-fewest in the NFL)
  • St. Brown has eclipsed 6.5 receptions just once over his past five games (six of 15 on the season)

Odds on Under 6.5 receptions sit at -105 to -110 across our best sports betting sites.

Brock Purdy Over 255.5 passing yards (-115) ⭐⭐⭐⭐

We’re looking for Brock Purdy to have a big game against a Detroit defense that has gotten leakier against the pass as the year has evolved.

  • The Lions rank 28th in pass defense (240.4 yards per game)
  • Across its last three games, as the injuries have mounted on defense, Detroit has surrendered an average of 294.7 passing yards per contest
  • Purdy has cleared this passing line in eight of 14 games played

DraftKings is on the lower end of the value spectrum for Over bettors on this prop, listing the number at 255.5 yards, while BetMGM offers it at 252.5 yards.

George Kittle Under 68.5 receiving yards (-120) ⭐⭐⭐⭐

This Under prop for a primary San Francisco pass-catcher is negatively correlated with our Over bet on Purdy’s passing yards, which juices up our SGP odds significantly.

  • While the Lions do give it up through the air, their deficiency is filtered specifically to the WR position; against tight ends, though, Detroit allows less production than anyone (35.20 yards per game)
  • No tight end has cleared this receiving line against the Lions this season
  • Kittle has fallen short of this receiving line in seven of his 13 games played

Although BetMGM offers a better line on Purdy’s passing yardage, the SGP odds at +650 pale in comparison to +750 at DraftKings. FanDuel at +740 is a fine option but less attractive than DraftKings due to Kittle’s receiving line at 66.5 yards instead of 68.5.

A winning $10 wager on this parlay at DraftKings would profit $75.00.

Lions vs. 49ers odds

See all of this week's NFL odds and NFL scores.

Monday Night Football game info

  • Matchup: Lions vs. 49ers
  • Kickoff: 8:15 p.m. ET
  • Where: Levi’s Stadium (Santa Clara, Calif.)
  • How to watch: ESPN
  • Weather: 55 degrees, 0% chance of precipitation, wind 7 mph NW
  • Favorite: Lions -3.5 (-105 via FanDuel)

NFL betting odds pages

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Written By:
Brenden Schaeffer
Brenden has covered the St. Louis Cardinals as a credentialed baseball writer for KMOV-TV since 2016. His sports writing has appeared in outlets including the Austin American-Statesman and Columbia Daily Tribune. Since 2021, Brenden has co-hosted 'The Big Show' during the afternoon drive for KTGR, the ESPN radio affiliate in Columbia, MO. He has appeared on radio stations around the country, including KMOX, and hosts a daily St. Louis Cardinals podcast. In the sports betting content space, Brenden has covered the NFL, college football, NBA, and college basketball for outlets including SBR since 2019. For his football handicapping, Brenden looks to target NFL player prop markets as well as sharp underdog lines in college football. Brenden looks to reference FanDuel for his sports betting articles because of its consistently competitive odds on parlays. FanDuel's boost offerings are also customer-friendly, and its odds on the NFL Same Game Parlay articles he's written for SBR have historically been consistently competitive compared to other books.