Machibet APPEagles vs. Colts Picks, Predictions Week 10: Can Philly Bounce Back From 1st Loss?

Coming off a Monday night loss to the Washington Commanders, the Philadelphia Eagles are touchdown-favorites to get back on track against the Indianapolis Colts. See if they will by reading our Eagles-Colts picks and predictions for Week 11.

Four turnovers ruined Philadelphia’s chances of a perfect season Monday in a 32-21 loss to the Commanders as double-digit favorites. The Eagles now head to Indianapolis on a short week to take on the Colts, who beat the Las Vegas Raiders last week in Jeff Saturday’s coaching debut and are still alive in the AFC playoff hunt.

Here are our Eagles-Colts picks and predictions for Week 11 (odds via PointsBet and BetMGM; pick confidence based on a 1-to-5-star scale).

Check out our NFL best bets and all of our top picks for Week 11.

Eagles vs. Colts Game Info

Date: Sunday, Nov. 20, 1 p.m. ET
TV: CBS
Location: Lucas Oil Stadium, Indianapolis, IN
Weather: 26 F, 0% chance of precipitation, 6-mph winds

Eagles vs. Colts Odds

Eagles vs. Colts Odds Analysis

Philadelphia was favored by as many as 10 points on the early lookahead lines but re-opened as a 7.5-point road favorite following its Monday night loss to Washington. The spread crossed through the key number of 7 after 68% of the early money came on Indy, but some sportsbooks have moved Philadelphia to -6.5 or even -6.

The total has drifted up a half-point to 44.

Eagles vs. Colts Picks

Spread: Colt s +7 (-107 via PointsBet)
Over/Under: Over 44 (-110 via BetMGM)
Prop: Eagles first half Over 13.5 (-105 via BetMGM)

Eagles vs. Colts ATS Pick

Colts +7 (-107) ★★★★

Everyone thought the Colts were tanking when they hired former offensive lineman Jeff Saturday - who had never coached above the high school level - to replace respected head coach Frank Reich. But after beating Las Vegas 25-20 last week, Indy is very much in the hunt for a playoff spot, entering this week’s action at 4-5-1 and 1.5 games behind New England for the final wild card in the AFC.

Veteran quarterback Matt Ryan made the most of the opportunity to get his starting job, throwing zero interceptions and getting sacked just once while adding a career-high 39-yard run. Saturday also seemed to have an influence on the Colts running game as Jonathan Taylor ran for 147 yards, the first time he’s cracked the century mark since the opening week.

Philadelphia looked invincible at times in an 8-0 start to the season, but the Eagles’ run defense looked vulnerable in Monday’s surprising 32-21 loss to Washington. Philly also struggled playing from behind in the second half for the first time this season, and now the Eagles will be without top tight end Dallas Goedert for at least a month. The Eagles are just 1-3 against the spread on the road this year (1-5 ATS on the road in their last six going back to last season) and I don’t see them winning by more than a touchdown on a short week.

Eagles vs. Colts O/U Pick

Over 44 (-107) ★★★

Philadelphia has scored at least 20 points in every game it’s played this year, and at least 26 in four of its last six. Philly would have put up more than 21 last week if not for a season-high four turnovers, including a fumble in the Washington red zone and an interception that should have been a long completion to star receiver A.J. Brown.

Indianapolis should also put up points in this spot after scoring 25 last week against the Raiders, Indy’s second-best offensive performance of the year. As long as the Colts are within a couple scores of the Eagles, expect a strong commitment to Taylor and the running game against an Eagles defense that has allowed opponents to average more than 150 rushing yards over the past three weeks. Philly has also struggled recently to rush the passer, generating just three sacks in its last five, so Ryan should have time to find his receivers downfield.

Eagles vs. Colts Prop Pick

Eagles first half Over 13.5 (-105) ★★★

Philadelphia has scored at least 14 first-half points in each of its nine games this season and has cashed its first-half team total Over in 10 of its last 12 games. Coming off a loss, the Eagles should also be motivated to get off to a fast start against an Indy team that often starts slow, getting outscored by an average of seven points in the opening half this year.

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Eagles-Colts picks made 11/17/2022 at 10:50 a.m. ET

Written By:
Connor Cooper

Connor Cooper has written about sports in various capacities for more than 20 years, including as a newspaper reporter, sports handicapper, and betting analyst. He originates hockey plays every day throughout the NHL season, regularly bets his own opinions on NFL and college football, and relies on handicappers he trusts to find daily action in basketball, baseball, soccer, tennis, and golf. A diehard Maple Leafs and Blue Jays fan growing up in the Toronto area, Connor quickly shed all his allegiances once he realized that making money betting on sports was much more fun than cheering for his favorite team. Connor won’t hesitate to bet on — or against — anybody if that’s where the value lies. In addition to analyzing recent and season-long statistics, Connor always looks to account for the human element when breaking down games, weighing situational and motivational factors into his handicapping process. He's also a big believer in finding creative ways to generate more value, constantly scouring BetMGM, Caesar, FanDuel, and other regulated sportsbooks' derivative markets such as team totals, alternate lines, and player props.