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Cowboys vs. Cardinals Predictions, Picks & Odds Week 3: Dallas Cruises to 3-0 Start

Philip Wood

Last Updated: September 24, 2023 3:26 PM EDT • 3 min 8 sec read.

The 2-0 Dallas Cowboys head into State Farm Stadium as a significant favorite over the Arizona Cardinals, as we share our top Cowboys vs. Cardinals predictions based on the NFL odds from our best sports betting apps. 

The Dallas Cowboys are rolling.

Big D has outscored opponents 70-10 through two games while surrendering a miniscule 386 total yards. Additionally, a trip to Glendale to face the 0-2 Arizona Cardinals should serve as the perfect opportunity for the offense to have its best showing of the season.

While the Cards have been competitive, they blew a 20-point lead to the New York Giants last week, and this is definitely the toughest test of the early season for Arizona.

To accompany our NFL best bets for Week 3 and all of our NFL Week 3 predictions, here is our best Cowboys vs. Cardinals prediction and NFL picks (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

Cowboys vs. Cardinals prediction

Cowboys -12.5 () ⭐⭐⭐⭐

This is a simple bet. The Cowboys are among the NFL's best teams, and the Cardinals are simply overmatched. Through two matchups, Arizona quarterback Josh Dobbs threw for just 360 yards, and he'll be under constant duress in this one. While Cowboys’ star cornerback Trevon Diggs is out for the season, it's not a matchup for any potential secondary weakness to be exposed.

Dallas has yet to face a very good QB, but it made New York Jets and Giants signal callers Zach Wilson and Daniel Jones, respectively, look downright awful. Its defensive line is a menace, and it'll have a field day against a Cardinals offensive line that has given up three sacks this year.

While the Cardinals lost close games, they’re still not a very good team. What they looked like in the second half against the Giants is what they should look like for the rest of the season. They average 22 points per game, but it'd be shocking to see them come anywhere near that number against a team with just 10 points allowed on the season.

The Cowboys average 35 points per game so expect them to get near their average again Sunday. When they do, Arizona won’t even come close to covering this spread.

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Cowboys vs. Cardinals best odds

DraftKingsFanDuelBetMGMCaesarsbet365
-12.5-12.5-12.5-12.5-12.5
-110-110-110-110

All of our best sports betting apps offer the same spread for the same price at the moment. The spread should continue to widen ahead of kickoff, so you could snag this at 13.5 or higher for a really good price. Keep monitoring this line as game time approaches. Also, don’t be afraid to take an alternate spread like 14.5 for +125 or better.

Cowboys vs. Cardinals odds

Cowboys vs. Cardinals odds analysis

The Cowboys opened as 9.5-point favorites, but with how they've looked so far this season, it’s no surprise that the spread grew to 12.5. More than 60% of bettors backed the favorites. Don’t expect this spread to hit any key numbers, but it’s more likely to hit 14 than 10.

As for the total, the number opened at 43, and stayed there despite 67% of bettors supporting the Over. With how good the Dallas defense has played, it’s hard to imagine this number going up much with Dobbs and Co. trying to decipher them.

Cowboys vs. Cardinals game info

  • When: Sunday, Sept. 24 at 4:25 p.m. ET
  • Where: State Farm Stadium, Glendale, AZ
  • How to watch: FOX
  • Weather: Indoors

Cowboys vs. Cardinals prediction made 9/22/23 at 12:26 p.m. ET

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Written By:
Philip Wood
Phil has covered sports betting since 2016, and he has been with SportsBook Review since 2022. He previously hosted the College Football Pick 'Em podcast for CanesInsight.com. He is always looking for value, especially on lines that just seem too good to be true. His belief is that if a line doesn't make sense just assume oddsmakers know something you don't. He also loves in-season futures. There is so much value to be had as the public overreacts weekly. Bettors tend to forget just how long NFL and college football seasons are. After all, the Green Bay Packers were 2-5 in 2023 and they made it to the Divisional Round. When deciding where to bet, it comes down to value over everything. +100 is always better than -110. An alumnus of The U, Phil always holds out hope that the next head coach will be the one who turns the football program around. He is also a diehard Detroit Lions fan and is willing to forgive Dan Campbell for forgetting that a kicker can be useful.