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Chargers vs. Colts Odds, Picks, Predictions Week 16: Will Indianapolis Recover From Historic Loss?

Mike Spector

Last Updated: December 26, 2022 11:20 AM EST • 1 min 57 sec read.

The Los Angeles Chargers look to clinch a postseason berth with a win over the Indianapolis Colts on Monday Night Football. Read on for our top Chargers-Colts NFL pick based on the best odds.

Los Angeles (8-6) hopes for its second three-game winning streak of the season. Its current two-game streak catapulted its odds of making the playoffs to 93% (per ESPN Analytics), as its final three opponents have a combined record of 12-28-1.

Indianapolis (4-9-1) lost four consecutive games, none worse than last week’s defeat against the Minnesota Vikings. The Colts squandered a 33-0 third-quarter lead and became the first team in NFL history to lose a game when leading by 33+ points. 

Here is our best Chargers vs. Colts NFL Week 16 pick (odds via ; pick confidence based on a 1-to-5-star scale).

Check out our Justin Herbert prop picks, Monday Night Football prop picks, and Colts-Chargers SGP.

Chargers vs. Colts Game Info

  • Date: Monday, Dec. 26, 8:15 p.m. ET 
  • TV: ESPN
  • Location: Lucas Oil Stadium, Indianapolis, IN
  • Weather: Indoors

Chargers vs. Colts Odds

Chargers vs. Colts Odds Analysis

The Chargers were installed as 2.5-point favorites and the spread has been bet as high as 4.5. It currently sits at 3.5, with 68% of the cash and 76% of the tickets on Los Angeles.

The Over/Under has been declining steadily from 48 to 45, and it's now commonly at 44.5. The Over is getting 63% of the cash and 65% of the tickets.

Chargers vs. Colts Pick

Over 45.5 ⭐⭐

The Colts start their third quarterback of the season, as Nick Foles is under center this week. While that alone will cause many to back the Under, Foles is not your average third-string QB, as he's a former Super Bowl MVP and has 56 career starts. Foles likely can't do much worse than previous starter Matt Ryan, who led the league in interceptions (13) and had the 25th-worst QBR (43.6).

Both the Chargers and Colts rank 23rd or worse in scoring defense. Expect a huge day offensively for L.A., facing an Indy D that allowed Vikings QB Kirk Cousins to throw for 417 yards in the second half/overtime last week (the most such yards in the previous 45 seasons).

The Colts gave up four plays of 35+ yards and two of 60+ yards, which means a healthy Chargers receiving corps should have a field day against a dejected defensive unit.  

Chargers vs. Colts Best Odds

DraftKings (-110)

DraftKingsFanDuelBetMGMCaesarsPointsBet
O 45.5 (-110)O 45.5 (-110)45.5 (-110)45.5 (-110)45.5 (-107)

With the sportsbooks completely aligned on the total as of Saturday afternoon, the winner once again is PointsBet by virtue of its three extra cents of value.

Chargers-Colts pick made 12/23/2022 at 6:30 a.m. ET.

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Written By:
Mike Spector
Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”