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Could the Buffalo Bills win as many games at Ford Field this season as the Detroit Lions? Find out with our Browns-Bills picks.

We were robbed of a thundersnow game when the NFL relocated the Bills game against the Cleveland Browns from Buffalo to Ford Field in Detroit. The relocation will certainly cost the Bills a lot of money, but unlike them, we are here to make money in Week 11.

Here are our best picks and predictions for the Week 11 matchup between the Browns and Bills (odds via PointsBetFanDuel Sportsbook and DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).

Check out our NFL best bets and all of our top picks for Week 11.

Browns vs. Bills Game Info

Date: Sunday, Nov. 20, 1 p.m. ET
TV: CBS
Location: Ford Field, Detroit, MI
Weather: Dome

Browns vs. Bills Odds

Browns vs. Bills Odds Analysis

The Bills are ranging from -7.5 to -8.5 favorites at a number of sportsbooks. Their loss of home-field advantage altered the number. 

The total ranges from 49.5 to 50. Prior to the move to Ford Field, the Over/Under had dropped all the way to 41 with forecasts calling for six feet of snow in Buffalo.

Browns vs. Bills Picks

Sbr Betting TicketThree Picks

Browns vs. Bills ATS Pick

Browns +8.5  (-115) ★★★★

Considering Buffalo has been dealing with practices over zoom and the relocation of their team for a game they thought was going to be played at home, I prefer the Browns in this matchup. In addition to losing home field advantage, don't be surprised if there are more Browns fans at Ford Field on Sunday than Bills fans. 

Since I only make the Bills a 7-point favorite over the Browns on a neutral field, I am taking Nick Chubb and the Browns on FanDuel at Browns +8.5 (-115). As I believe Browns +7.5 might become a consensus line, I would jump on this number quickly. 

The best price is offered by FanDuel on this line, as you are getting a full point more than you would at other sportsbooks while only paying five cents in juice. 

Browns vs. Bills O/U Pick

Under 49.5 (-107) ★★★

With everyone pounding the Under when the game was slated to take place in a blizzard in Buffalo, I think the immediate thought is to play the Over since it has been moved to a dome. Not so fast, I have a different opinion about this number. 

A major mismatch between the Bills offense and Browns defense would lead to most of the points. There is a problem here in that the Bills offense has been working on a game plan to play in the wind and snow all week. That can be thrown away, but the real problem now is that the Bills were forced to cancel practice due to snow right after the game plan was altered. 

I have this total at 49, so a slight edge to the Under, but I believe some of the external factors that I discussed above make the edge even greater. All the sportsbooks are trading at 49.5, but PointsBet has the 14-cent line (-107), the best price for this total. 

Browns vs. Bills Prop Pick

Peoples-Jones anytime touchdown (+255) ★★★

Browns quarterback Jacoby Brissett has made wideout Donovan Peoples-Jones one of his favorite targets as the season has progressed. Despite having more than 70 yards receiving in each of his last four games, Peoples-Jones has failed to find the end zone in any of those games. 

All of that changes this week as the Detroit native and former Michigan Wolverine will have the opportunity to have a homecoming game with the relocation to Ford Field. It's only a matter of time before someone with the usage of Peoples-Jones scores a touchdown, and I believe you're getting a nice price at +255. 

Where to Bet on Browns-Bills Picks

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Browns-Bills picks made 11/18/2022 at 8:30 a.m. ET