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We're backing Braden Smith in our Indiana vs. Purdue prediction.
Pictured: Purdue guard Braden Smith dribbles the ball while guarded by Washington guard Zoom Diallo. Photo by Steven Bisig via Imagn Images.

In a rivalry that runs deep with hate in the Hoosier state, Indiana (14-7) takes on Purdue (16-5) tonight at 8 p.m. ET (FOX) at Mackey Arena in West Lafayette, Ind. 

Our Indiana vs. Purdue prediction and odds state the case for why the Boilermakers will trounce a struggling Hoosiers team that's a 12-point road underdog.

Indiana vs. Purdue predictions today

College basketball picks based on the odds from our best March Madness betting sites.

  • Against the spread pick: Purdue -12 () vs. Indiana ⭐⭐⭐⭐
  • My best pick: Braden Smith Over 8.5 assists () ⭐⭐⭐⭐

Indiana vs. Purdue ATS prediction

Purdue to cover the spread: -12 ⭐⭐⭐⭐

It appears Mike Woodson is in his last few weeks as Indiana's head coach. Despite the Hoosiers spending NIL money like it's growing on trees to bolster their roster ahead of the season, it's all been for not. Indiana is 1-4 in its last five games, including two 25-point thumpings. 

Even the presence of Oumar Ballo in the frontcourt can't seem to save this team. Indiana is just 65th in adjusted defensive efficiency, per , and it's allowing the fifth-most points per game in the Big Ten (77.9). That's a huge reason why Indiana is 3-5 against the spread as an underdog this campaign.

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Meanwhile, Purdue is a fringe March Madness odds contender and has been handling the loss of Zach Edey well, as the Boilermakers are 8-2 ATS against Big Ten opponents. Matt Painter's squad boasts the best offense in the conference while sitting seventh in adjusted offensive efficiency. The team is also allowing the fewest points per game in Big Ten play (65.2).

With Purdue currently projected to earn a No. 3 seed in the NCAA Tournament, according to , the Boilermakers should hammer this middling Indiana team. If they do, a $10 bet pays a $9.09 profit.

Best odds: -110 via Caesars | Implied probability: 52.38%

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Best Indiana vs. Purdue pick

Our NEW college basketball player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Braden Smith Over 8.5 assists ⭐⭐⭐⭐

Losing one of the most decorated players in collegiate basketball history could mean a rebuilding year for some programs, but that hasn't been the case for Purdue. Point guard Braden Smith has been elevating his game to help hide the 7-foot-4 absence in the middle for the Boilermakers, and he's even become a Wooden Award odds contender himself.

Among the best passers in college basketball, Smith is third in the country in assists per game (8.9) and is dishing out nine per outing against Big Ten opponents. He's also getting the perfect opportunity to reach double-digit apples against Indiana, which is 324th in assists allowed per outing this season (14.0).

With this same prop being offered at -150 at our other best sports betting sites - implying a 60% probability it hits - this is actually a great value opportunity at bet365. A $10 winning bet would pay a $7.41 profit.

Best odds: -135 via bet365 | Implied probability: 57.45%

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Live Indiana vs. Purdue odds

See all of this week's college basketball odds and NCAAB scores.

Indiana vs. Purdue opening odds

  • Spread: Indiana +12 (-105) | Purdue -12 (-115)
  • Over/Under: Over 146 (-110) | Under 146 (-110)
  • Moneyline: Indiana +650 | Purdue -1000

Indiana vs. Purdue game info

  • When: Friday, Jan. 31
  • Tipoff: 8 p.m. ET
  • Where: Mackey Arena (West Lafayette, Ind.)
  • How to watch: FOX
  • Favorite: Purdue -12 ()

College basketball betting odds pages

Here are our best March Madness betting sites:

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