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Penn State vs. Indiana Picks, Predictions College Football Week 10: Can Hoosiers Snap Losing Skid?

Hayley McGoldrick

Last Updated: November 5, 2022 5:59 AM EDT • 2 min 10 sec read.

Indiana's five-game losing skid includes last week's 24-17 loss to lowly Rutgers. The Hoosiers no face a tougher test, albeit at home, against No. 15 Penn State. Read on for our top Penn State-Indiana picks and predictions.

The Penn State Nittany Lions nearly upset now-No. 2 Ohio State before falling 44-31 last week. They'll look to rebound against a manageable opponent in the Indiana Hoosiers. The Hoosiers are just 3-5 both straight up and against the spread.

Penn State won last year's meeting 24-0 at home and covered a 12-point spread.

Here are our Penn State-Indiana college football picks for Week 10 (odds via DraftKings Sportsbook, FanDuel Sportsbook, and Caesars Sportsbook; pick confidence based on a 1-to-5-star scale).

Check out our college football best bets and all of our top picks for Week 10.

Penn State vs. Indiana Game Info

Date: Saturday, Nov. 5, 3:30 p.m. ET
TV: Big Ten Network, Fox Sports
Location: Memorial Stadium, Bloomington, Indiana
Weather: 64 degrees, 80% chance of precipitation, 20-mph winds

Penn State vs. Indiana Odds

Penn State vs. Indiana Odds Analysis

Despite heavy betting action on the visitors, the consensus spread dipped from the consensus opening line of Penn State -14 to -13.5 as of Saturday morning. The Nittany Lions have drawn 78% of the handle on 74% of the tickets.

The Over/Under has dropped from the opening number of 54.5 to 51. While 58% of the tickets are on the Under, those account for a modest 49% of the handle.

Penn State vs. Indiana Picks

  • Spread: Penn State -14 (-110 via Caesars)
  • Over/Under: Over 50 (-110 via DraftKings)
  • Prop: Parker Washington anytime TD scorer (+145 via FanDuel)

Penn State vs. Indiana ATS Pick

Penn State -14 (-110) ★★★★

Penn State has scored 265 points this season and allowed just 176, while Indiana has a negative point differential after scoring 196 total points and allowing 245 on the year.

The Hoosiers lost by 21 points to Michigan in their only game against a ranked opponent, but they have lost by 14 or more points in three of their last five games.

Penn State’s only two losses have come to ranked teams, though it has earned three victories by 14-plus points against unranked opponents.

Penn State vs. Indiana O/U Pick

Over 50 points (-110) ★★★

The Nittany Lions have hit this Over in each of their last three games and have scored fewer than 31 points in a game only twice this season.

Indiana has hit this Over in three of its previous five games, scoring at least 21 points in six of its eight games this season.

The Hoosiers are averaging 24.5 points per game, while the Nittany Lions are averaging 33.1 points per contest. Look for both offenses to put up points while trying to get back in the win column on Saturday.

Penn State vs. Indiana Prop Pick

Washington anytime TD scorer (+145) ★★★★

Washington didn’t score a touchdown through the first six games of Penn State’s season, but he’s been more involved of late by scoring a touchdown in each of the last two outings.

Washington had a season-high 11 receptions and 179 yards against Ohio State, following a performance where he turned seven targets into 70 yards and a touchdown against Minnesota.

Indiana’s passing defense is allowing 2.4 touchdowns per game on average, and Penn State will be looking to utilize the sophomore wide receiver in this matchup.

Where to Bet on Penn State vs. Indiana Picks

Here are our top-rated sportsbooks:

Penn State-Indiana picks made 11/3/2022 at 3:30 p.m. ET

Written By:
Hayley McGoldrick
Hayley McGoldrick is a Sports Betting Analyst at 520ccc.com. After primarily writing about basketball, football, and soccer for the bulk of her career, Hayley covers markets in the NCAAF, Premier League, and international soccer by previewing matches, conferences, and futures. An Ohio State fan since birth and an Arsenal fan by choice, Hayley is used to having high hopes that are crushed by the end of the season. Hayley holds a bachelor's degree in science from Wilfrid Laurier University and a diploma in Sports Journalism from Centennial College. You can find her watching sports, reading about sports, tweeting about sports, or at a concert.