Ohio State vs. Oregon Prediction & Picks: CFP Rose Bowl Odds

This year’s Rose Bowl could mark the unofficial national championship game when Ohio State (11-2) and Oregon (13-0) square off on Wednesday at 5 p.m. ET (ESPN).

While the winner of Wednesday’s showdown would still have to win two more games to claim the national title, this could be the most difficult challenge for either team. The regular-season meeting was decided by a single point, with Oregon claiming a 32-31 home win over Ohio State on Oct. 12.

The Buckeyes are 2.5-point favorites in the rematch, but my Ohio State vs. Oregon prediction backs the Ducks as we continue our college bowl game predictions this week.

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Ohio State vs. Oregon prediction & best pick: CFP Rose Bowl

College football picks based on the odds from our best college football betting sites. Odds subject to change.

• Against the spread pick: Oregon +2.5 () vs. Ohio State ⭐⭐⭐
• My best pick: Jeremiah Smith anytime touchdown () ⭐⭐⭐⭐

Ohio State vs. Oregon ATS prediction

Oregon to cover the spread: +2.5 ⭐⭐⭐

Best odds: -110 via BetMGM | Implied probability: 52.38%

I have one rule for betting on College Football Playoff games: trust the team with the edge in the trenches. Line play is consistently the most important aspect of the game when the stakes are highest.

That could be bad news for the Buckeyes. They have a banged up offensive line between Josh Simmons and Seth McLaughlin being out, while Zen Michalski has entered the portal.

The Ducks rank fifth in the country in pass-rush grade (PFF), so they can make life difficult for OSU quarterback Will Howard. Oregon’s offensive line is also trustworthy, ranking in the top 30 in both run-blocking and pass-blocking grades.

Dan Lanning’s team has been my favorite college football championship odds pick since January. I’m backing the Ducks off a bye in their most important contest in years.

Ohio State vs. Oregon best pick

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Jeremiah Smith anytime touchdown ⭐⭐⭐⭐

Best odds: +100 via FanDuel  | Implied probability: 50%

Oregon’s defensive line should decide this game, but Ohio State won’t be stopped entirely on Wednesday. The Buckeyes have too many weapons, including freshman receiver Jeremiah Smith.

Smith caught nine passes for 100 yards and a touchdown against Oregon when these teams met earlier in the season. Smith admitted that he’s a better receiver today than he was in that game, a statement that would typically seem bold if he hadn’t just scored two touchdowns against Tennessee.

Smith has scored 12 touchdowns this season, shredding any cornerback that attempts to defend him one-on-one. His chances of scoring a touchdown are better than a coin-flip, particularly since this could be a high-scoring affair.

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Ohio State vs. Oregon odds

See all of this week's college football odds and NCAAF scores.

Ohio State vs. Oregon live odds

Ohio State vs. Oregon opening odds:

• Ohio State: -1.5 (-110 via BetMGM)
• Oregon: +1.5 (-110 via BetMGM)

Ohio State vs. Oregon injuries

CFP Rose Bowl game info

• When: Wednesday, Jan. 1
• Kickoff: 5 p.m. ET
• Where: Rose Bowl (Pasadena, Calif.)
• How to watch: ESPN
• Weather: 70 degrees, 0% chance of precipitation, 14 mph S winds
• Favorite: Ohio State -2.5 (-110 via BetMGM)

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