Notre Dame vs. USC Early Picks, Predictions & Odds Week 14

Notre Dame lost a home game to a mediocre MAC school and has spent the rest of the season working to make up for it.

I’ve remained a skeptic, but after the Fighting Irish ran roughshod over Army last weekend, I’m ready to buy into them as College Football Playoff odds favorites.

Our Notre Dame vs. USC predictions and odds see the Irish ending the regular season on a high note against a middling Trojans side that barely clinched bowl eligibility with a win over UCLA.

Will there be much left in the tank to fend off the Irish when USC hosts Notre Dame on Saturday? We break it down as part of our Week 14 college football predictions. 

My early Notre Dame vs. USC prediction

College football picks made Monday; odds subject to change. Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Prediction: Notre Dame -7

Best odds: | Implied probability: 53.49%

Giving a touchdown to USC at home is a dangerous game considering the Trojans are 5-0 ATS at home this season. But when everyone remembers your team for an outright loss as four-touchdown favorites, the mindset of proving your worth doesn’t cease.

This Notre Dame team has played with a chip on its shoulder to ensure it would not be remembered only for its worst moment. The Irish have an 8-2-1 ATS record, tying them for the fourth-best cover rate in FBS this season.

Removing the Northern Illinois result, Notre Dame has averaged an otherworldly +15.45 margin per game against the spread this season.

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Notre Dame vs. USC live odds

See the college football odds from our best college football betting sites for every Week 14 game.

Moneyline

• Notre Dame best odds: -250 via BetMGM | Implied probability: 71.43%
• USC best odds: +220 via bet365 | Implied probability: 31.25%

BetMGM and FanDuel are the most reasonable best sports betting sites to back the Notre Dame ML as those books still list -250 odds. Elsewhere, it’s up to -265 or higher.

The favorable lean for Notre Dame bettors at those spots makes them locations to avoid for USC backers. Those looking to bet the USC ML should seek out the +220 odds from bet365 or +215 odds from DraftKings and Caesars.

Spread

• Notre Dame best odds: -7 (-115) via Caesars
• USC best odds: +7.5 (-112) via DraftKings

The line originally opened at Notre Dame -3.5, but with 74% of bets being placed on the Irish, the number is up to -7.5 at DraftKings, FanDuel, and BetMGM. At Caesars and bet365, you can still catch the Irish at -7. USC’s home success should keep this spread from getting out of hand, but we don’t expect it to move back below -7.

Over/Under

• Over best odds: 51 (-110) via bet365
• Under best odds: 51 (-110) via BetMGM

The total opened at 50.5 and has been rising in early betting. The only book that currently strays from listing the total at 51.5 is bet365, so that’s the best spot to wager the Over.

How to watch Visitor vs. Host

• When: Saturday, Nov. 30
• Kickoff: 3:30 p.m. ET
• Where: Los Angeles Memorial Coliseum, Los Angeles, Calif.
• How to watch: CBS
• Weather: 76 degrees, 9% chance of precipitation, wind 2 mph NW
• Favorite: Notre Dame -7 (-115 via Caesars)

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