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Michigan State vs. Illinois Picks, Predictions College Football Week 10: Fighting Illini to Continue Strong Play

Hayley McGoldrick

Last Updated: November 5, 2022 6:02 AM EDT • 1 min 39 sec read.

The Illinois Fighting Illini opened at No. 16 in the College Football Playoff ranking and welcome the Michigan State Spartans in Week 10. Read on for our top Michigan State-Illinois picks.

With quarterback Tommy DeVito and running back Chase Brown at the helm, it seems nothing can stop Illinois’ offense. However, Michigan State wants to change that to get out of its slump which includes losses in five of its last six games.

Here are our top picks for the college football Week 10 game between Michigan State and Illinois (odds via DraftKings Sportsbook, BetMGM, and FanDuel Sportsbook; pick confidence based on a 1-to-5-star scale).

Check out our college football best bets and all of our top picks for Week 10.

Michigan State vs. Illinois Odds

Michigan State vs. Illinois Picks

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Michigan State vs. Illinois ATS Pick

Illinois -17.5 (-102) ★★★★

The Fighting Illini are on track to a Big Ten title game, as they sit ranked 14th in the country and are averaging 409.8 yards per game, with 197 of those yards on the ground thanks to star running back Brown.

Michigan State is 3-4-1 and has lost five of its last six games this season, beating only Wisconsin in double overtime.

With Illinois’ defense ranked No. 1 in the country in points allowed and second in yards allowed, it will make it tough for a Michigan State offense that is averaging just 16.2 points per game and has already lost to four Big Ten opponents.

Michigan State vs. Illinois O/U Pick

Under 42 (-110) ★★★

Illinois’ stellar defensive play has kept its opponents to less than 15 points in all but one game this season, its lone loss to Indiana by three points.

The Fighting Illini have hit the Under 41.5 mark in five of their last six games, while Michigan State has been held to 13 points or less three times this season against Big Ten opponents.

With the Illini securing their first winning regular-season record since 2007, they will look to stretch their streak to seven and hold Michigan State to Under its 16-point game average.

Michigan State vs. Illinois Prop Pick

Michigan State +5.5 first half (+175) ★★★

The Fighting Illini have been a consistent second-half team this season, while the Spartans have found more luck scoring first against their opponent before falling apart in the second half.

Illinois has led by six or fewer points in three of its last four matchups against Big Ten opponents, while Michigan State has managed to score at least seven points in the first quarter of all of its last four games.

Where to Bet on Michigan State-Illinois Picks

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Michigan State-Illinois picks made 11/03/2022 at 12:30 p.m. ET

Written By:
Hayley McGoldrick
Hayley McGoldrick is a Sports Betting Analyst at 520ccc.com. After primarily writing about basketball, football, and soccer for the bulk of her career, Hayley covers markets in the NCAAF, Premier League, and international soccer by previewing matches, conferences, and futures. An Ohio State fan since birth and an Arsenal fan by choice, Hayley is used to having high hopes that are crushed by the end of the season. Hayley holds a bachelor's degree in science from Wilfrid Laurier University and a diploma in Sports Journalism from Centennial College. You can find her watching sports, reading about sports, tweeting about sports, or at a concert.