Machibet LiveKentucky vs. Missouri Picks, Predictions College Football Week 10: SEC Defensive Struggle on Tap

Missouri enters its Week 10 home date with Kentucky as a slight favorite off of back-to-back wins to improve to .500 for the season. Read on for our top Kentucky-Missouri picks and predictions.

October was a month to forget for the Kentucky Wildcats. They entered at 4-0 and were considered one of the best teams in the country. Now, they have lost three of their last four games, the most recent of which was a 44-6 shellacking at the hands of Tennessee last week.

Meanwhile, after a rough start to the season, Missouri has managed to win two games in a row. The Tigers will look to keep their win streak going this week before they head to Tennessee to take on the No. 1 team in the country next Saturday.

Here are our Kentucky versus Missouri college football picks for Week 10 (odds via BetMGM, FanDuel Sportsbook, DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).

Check out our college football best bets and all of our top picks for Week 10.

Kentucky vs. Missouri Game Info

Date: Saturday, Nov. 5, noon ET
TV: SEC Network
Location: Memorial Stadium/Faurot Field, Columbia, MO
Weather: 58 degrees, 55% chance of precipitation, 15-mph winds

Kentucky vs. Missouri Odds

Kentucky vs. Missouri Odds Analysis

The consensus spread moved sharply in favor of Missouri. The Tigers opened as 2.5-point underdogs and are 1-point favorites as of Saturday morning. While 64% of the tickets back Kentucky, 56% of the handle is on Missouri.

Betting action seems to have dropped the consensus total from 44 to 40.5 as of Saturday morning. The Under has drawn 59% of the tickets and an impressive 72% of the handle.

Kentucky vs. Missouri Picks

Moneyline: Kentucky (-111 via FanDuel) ★★★★
Over/Under: Under 41 (-110 via BetMGM) ★★
Prop: Missouri Under 20.5 points (-135 via DraftKings) ★★★

Kentucky vs. Missouri ML Pick

Kentucky (-111) ★★★★

This line feels like a what-have-you-done-for-me-lately scenario. The Tigers just defeated a top-25 team in South Carolina, even if the Gamecocks had no business being ranked. That same weekend, the Wildcats got absolutely embarrassed in Tennessee, 44-6.

Yet, when you look at what these two teams have done as a whole this season, the Wildcats are the clear play. Their losses were at Mississippi, at Tennessee, and at home against South Carolina. They have wins over Mississippi State and Florida, and they are only allowing 19.9 points per game.

With the exception of South Carolina, the Tigers’ four wins this season have been unimpressive victories over weak competition. Just two weeks ago, they very nearly lost a home game to Vanderbilt. The Wildcats will erase the embarrassment of last week, and secure bowl eligibility with a satisfying road victory.

Kentucky vs. Missouri O/U Pick

Under 41 (-110) ★★

Both of these teams have been caught in low-scoring affairs all season. The Tigers have held four of their last six opponents under 20 points, and the Wildcats have scored more than 20 in just one of their last four games.

This total is very low, but it would be surprising to see either of these teams score four touchdowns or more. After all, they have only done it five times combined this season. This number is likely going to keep going down. So, get in quickly at the highest number you can find, then enjoy an old-school SEC defensive struggle.

Kentucky vs. Missouri Prop Pick

Missouri team total Under 20.5 (-135) ★★★

Realistically, neither of these teams is going to hit 21 points. Therefore, picking either Kentucky or Missouri Under 20.5 points is a solid play. However, we’re going with the Tigers as a more sure thing because they are coming off their biggest win of their season, and they are about to face one of the best defenses they’ve come up against.

The Tigers have broken 20 just twice this season against Power 5 competition and they barely did so, hitting 22 and 23 points. Going up against a good defensive team that is playing for pride after being blown out last week is not a recipe for much scoring for the Tigers.

Where to Bet on Kentucky vs. Missouri

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Kentucky vs. Missouri picks made 11/2/2022 at 10:28 p.m. ET

Written By:
Philip Wood

Phil has covered sports betting since 2016, and he has been with SportsBook Review since 2022. He previously hosted the College Football Pick 'Em podcast for CanesInsight.com. He is always looking for value, especially on lines that just seem too good to be true. His belief is that if a line doesn't make sense just assume oddsmakers know something you don't. He also loves in-season futures. There is so much value to be had as the public overreacts weekly. Bettors tend to forget just how long NFL and college football seasons are. After all, the Green Bay Packers were 2-5 in 2023 and they made it to the Divisional Round. When deciding where to bet, it comes down to value over everything. +100 is always better than -110. An alumnus of The U, Phil always holds out hope that the next head coach will be the one who turns the football program around. He is also a diehard Detroit Lions fan and is willing to forgive Dan Campbell for forgetting that a kicker can be useful.