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Iowa State vs. Oklahoma State Picks, Predictions College Football Week 11: Sputtering Teams Meet in Stillwater

Philip Wood

Last Updated: November 9, 2022 7:32 AM EST • 2 min 17 sec read.

The Iowa State Cyclones have lost five of their last six games, while the Oklahoma State Cowboys have lost two in a row and could be without their starting quarterback Spencer Sanders. Read on for our Iowa State-Oklahoma State picks.

The Cyclones ended their five-game losing streak with a 31-14 win over West Virginia last week. They led from start to finish, even building up a 24-point lead at one point.

Meanwhile, the Cowboys have dropped out of the Top 25 after losing two games in a row. Last week, they were without starting quarterback Spencer Sanders, and they managed just 16 points while turning the ball over four times.

Here are our top picks for the college football Week 11 game between Iowa State and Oklahoma State (odds via DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).

Check out our college football Week 11 roundup, games to watch, and best against-the-spread picks.

Iowa State vs. Oklahoma State Game Info

Date: Saturday, Nov. 12, 3:30 p.m. ET
TV: ESPNU
Location: Boone Pickens Stadium, Stillwater, OK
Weather: 48 degrees, 0% chance of precipitation, 7-mph winds

Iowa State vs. Oklahoma State Odds

Iowa State vs. Oklahoma State Odds Analysis

The Cyclones opened as 1.5-point favorites, and they have remained favorites throughout the week. There has been a slight drop at DraftKings, but the line has stayed put at the other major sportsbooks. Once Sanders is officially ruled out, look for this number to move in the Cyclones’ favor.

The total opened at 48.5, and it has stayed there for now.

Iowa State vs. Oklahoma State Picks

  • Spread: Iowa State -1 (-110)
  • Over/Under: Under 48.5 (-110)
  • Prop bet: Oklahoma State Under 23.5 (-110)

Iowa State vs. Oklahoma State ATS Pick

Iowa State -1 (-115) ★★★

If Sanders plays, which seems unlikely right now, then the Cowboys are the correct play. However, without Sanders, the Cowboys’ offense is going to be in a lot of trouble against a defense allowing just 16.3 points per game.

Backup quarterback Garret Rangel did throw for 304 yards and two touchdowns for the Cowboys last week, but his three interceptions were very damaging for his offense.

During their five-game losing streak, the Cyclones lost all but one game by seven or fewer points. Meanwhile, the Cowboys have been outscored by 69 points in their last two games. These are two teams heading in different directions, and the Cyclones absolutely need this one to secure bowl eligibility.

Iowa State vs. Oklahoma State O/U Pick

Under 48.5 (-110) ★★★★

The Cowboys have scored just 16 points in their last two games, and without Sanders, their offense simply is not the one that was putting up over 40 points per game with him.

Only three of the Cyclones’ games have cleared this number this season, and two of those outcomes occurred when Iowa State scored more than 40. Against Big 12 competition, it's had just one game finish with a total in the 50s, while the other five have been in the 40s or lower.

The Cyclones have faced very good offenses this season and kept almost all of them below 30 points. With Rangel under center, the Cowboys are average at best.

Iowa State vs. Oklahoma State Prop Pick

Oklahoma State Under 23.5 (-110) ★★★

The Cowboys are a perfect 5-0 at home this season, and they scored 41 points in four of those five games. However, Sanders was their quarterback in each contest.

The Cyclones have been great defensively no matter where they play. Only three of their opponents have scored 24 or more points against them this season. They have given up 24 or more in two of their last three games, but those results came against healthy Texas and Oklahoma teams.

Expect the Cowboys’ offensive struggles to continue and Iowa State to hold them below 20.

Where to Bet on Iowa State-Oklahoma State Picks

Iowa State-Oklahoma State picks made 11/09/2022 at 8:42 a.m. ET

Written By:
Philip Wood
Phil has covered sports betting since 2016, and he has been with SportsBook Review since 2022. He previously hosted the College Football Pick 'Em podcast for CanesInsight.com. He is always looking for value, especially on lines that just seem too good to be true. His belief is that if a line doesn't make sense just assume oddsmakers know something you don't. He also loves in-season futures. There is so much value to be had as the public overreacts weekly. Bettors tend to forget just how long NFL and college football seasons are. After all, the Green Bay Packers were 2-5 in 2023 and they made it to the Divisional Round. When deciding where to bet, it comes down to value over everything. +100 is always better than -110. An alumnus of The U, Phil always holds out hope that the next head coach will be the one who turns the football program around. He is also a diehard Detroit Lions fan and is willing to forgive Dan Campbell for forgetting that a kicker can be useful.