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College Football Games to Watch Week 11: Matchups, Info, Odds

Henry John

Last Updated: January 1, 0001 12:00 AM EST • 4 min 21 sec read.

Looking at the biggest matchups and most interesting betting lines for Week 11 of the 2022 college football season.

Only three weeks remain in the 2022 college football regular season. Bye weeks are essentially a thing of the past for all FBS schools at this point. As such, bettors will have full slates to choose from for the remainder of the year. 

After all of the chaos that went down last Saturday, what can Week 11 possibly have in store as an encore act? While it’s highly unlikely that three of the top six teams in the CFP rankings will lose outright for the second week in a row, plenty more surprises could be in store. With several ranked teams facing tough conference tests, we could be in for yet another wild weekend.

Here are the top seven games to watch in Week 11 of the 2022 college football season (all odds via DraftKings Sportsbook).

College Football Week 11 Games to Watch

(19) Liberty vs. UConn

Date: Saturday, Nov. 12, Noon ET
TV: CBSSN
Location: Pratt and Whitney Stadium, East Hartford, CT
Odds: LIB -14.5 | O/U 46

Yes, there are some other games in Saturday’s noon window involving higher-profile schools, namely an SEC clash between LSU and Arkansas. That said, how can we not show some love to a pair of overachieving FBS Independents?

The big question here is whether or not the Flames will be caught reading their press clippings after last week’s statement win. If so, UConn could very well prove to be a difficult out at home. Against all odds, Jim Mora Jr. has the Huskies one win away from bowl eligibility in his first season at the helm. Could UConn’s sixth win actually come against a Top 25 opponent?

Louisville vs. (12) Clemson

Date: Saturday, Nov. 12, 3:30 p.m. ET
TV: ESPN
Location: Memorial Stadium, Clemson, SC
Odds: CLEM -7 | O/U 51.5

How will Clemson respond after taking one on the chin last week at Notre Dame? One thing we can say is that the Tigers would’ve much rather faced Louisville earlier in the year. Malik Cunningham and the offense seem to have found their groove over the course of a four-game winning streak. The Cardinals will try to hand Clemson its first conference loss on Saturday.

One has to assume that the Tigers still control their own destiny with regard to the College Football Playoff. Clemson is virtually locked into the ACC Championship Game given that all other teams in the Atlantic Division already have two conference losses. That said, seven points seems like a lot to lay this week based on the recent trajectories of these two teams.

(10) Alabama vs. (11) Ole Miss

Date: Saturday, Nov. 12, 3:30 p.m. ET
TV: CBS
Location: Vaught-Hemingway Stadium, Oxford, MS
Odds: ALA -11.5 | O/U 63.5

Any chance Alabama or Ole Miss have of winning the SEC West Division is dependent on Saturday’s massive showdown at The Vaught. After losing to LSU last week, the Crimson Tide are basically out of the running for the College Football Playoff. Having to now turn around and play on the road against a Rebels team fresh off a bye makes for a brutal scheduling spot.

Despite the fact that Ole Miss comes in with a better record, oddsmakers opened Alabama as a double-digit road favorite. The opening spread of 10.5 points has now risen to 11.5 or higher across the market. The Tide have won each of the last six head-to-head meetings between the teams, but the spot certainly screams to back the rested Rebels as a home ‘dog.

(22) UCF vs. (16) Tulane

Date: Saturday, Nov. 12, 3:30 p.m. ET
TV: ESPN2
Location: Yulman Stadium, New Orleans, LA
Odds: TUL -2 | O/U 53

For all intents and purposes, the showdown between UCF and Tulane can pretty much be considered a play-in for the AAC Championship Game. Of course, a win in the conference title game could very well result in a New Year’s Six Bowl berth. Early betting action has seen an opening line of pick ’em shift to now favor the host Green Wave by two points.

With a win on Saturday, the Knights would hold the head-to-head tiebreaker over both Tulane and Cincinnati. Meanwhile, a win over UCF would give the Green Wave some much-needed margin for error given that they face Cincinnati on the road in two weeks. The stakes certainly can’t get much higher for this ranked matchup.

(1) Georgia vs. Mississippi State

Date: Saturday, Nov. 12, 7 p.m. ET
TV: ESPN
Location: Davis Wade Stadium, Starkville, MS
Odds: UGA -17 | O/U 53.5

Georgia asserted its dominance over the entire SEC in a big way last week. After dictating terms throughout in a statement home win over previously unbeaten Tennessee, the last thing anyone is expecting is for the Bulldogs to lose to Mississippi State as a 17-point favorite. Kirby Smart better have his troops ready for a true dogfight (pun fully intended) on Saturday night. 

Mississippi State may not be in contention for the SEC title, but the Bulldogs have plenty of talent. Mike Leach’s squad is perfect at home in Starkville this season. With another road game against Kentucky looming next week, this is a very tricky spot for Georgia.

(24) Washington vs. (6) Oregon

Date: Saturday, Nov. 12, 7 p.m. ET
TV: FOX
Location: Autzen Stadium, Eugene, OR
Odds: ORE -13.5 | O/U 72.5

All of the chaos that transpired around the country last week certainly helped a team like Oregon. Having won every game since a season-opening loss to Georgia, the Ducks are the highest-ranked Pac-12 team and in control of their own destiny with regard to making the conference title game.

Saturday’s matchup against Washington kicks off a grueling three-game finish to the regular season. However, based on how dominant the Ducks have been in Pac-12 play, it’s hard to argue with the fact that they are laying nearly two touchdowns at home. Bo Nix and the offense have been phenomenal. Oregon has now scored 40-plus points in eight straight games.

(4) TCU vs. (18) Texas

Date: Saturday, Nov. 12, 7:30 p.m. ET
TV: ABC
Location: DKR-Texas Memorial Stadium, Austin, TX
Odds: TEX -7 | O/U 65

No, that’s not a typo. Fourth-ranked and undefeated TCU is catching a full touchdown as a road underdog at Texas ahead of Saturday’s primetime matchup. Needless to say, a win here would go a long way toward Texas punching its ticket to the conference title game.

All season long, the Longhorns have consistently been power rated as the best team in the Big 12. However, bettors can confidently assume that TCU will be a very public underdog this week. Early-week betting splits at DraftKings already show that 80% of all ATS bets and even 70% of moneyline tickets are on the Horned Frogs.

Where to Bet on Week 11 College Football

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Written By:
Henry John
Henry’s passion for sports dates all the way back to childhood and has ultimately led to a full-fledged career as an analyst and content creator. After getting his start penning fantasy football articles, he forrayed into the betting side of the business in early 2019. His love for sports and statistics proved to be an ideal match with the dedicated research and strategy that handicapping requires. Henry currently specializes in betting analysis and picks for college football, college basketball, and NASCAR. He counts NFL, WNBA, and NBA player props as additional leagues/markets of interest. Henry graduated from SUNY Buffalo in 2021 with a Communication Studies degree and a Psychology minor. A native of the Finger Lakes region in Upstate New York, he and his pup, Harold, have since relocated to Laramie, Wyoming. Thanks to his professional goals within the sports betting industry, there has been a whole lot of steam on the odds for a move to Las Vegas in 2023! Most of Henry’s free time is spent on outdoor adventures, playing chess, snowboarding, or reading a good book. He is also a competitive powerlifter and aspires to qualify for the USAPL Nationals meet within the next 2-3 years.