Machibet777 LiveClemson vs. Notre Dame Picks, Predictions College Football Week 10: Can Tigers extend Win Streak?

Clemson enters its marquee Week 10 battle with Notre Dame sitting at No. 4 in the College Football Playoff ranking. A statement win will help the Tigers retain that coveted position. Read on for our top Clemson-Notre Dame picks.

Something needs to give in this matchup, as Clemson puts its 14-game winning streak (the longest active one in the country) against Notre Dame's 14-game home winning streak when facing ACC opponents.

The Tigers have earned six-point victories in each of their last two games, but they still own a 17.3 points per game differential in 2022. Meanwhile, the Fighting Irish are looking to ensure that home losses to Marshall and Stanford as -20.5 and -16.5 point favorites, respectively, are long behind them.

Here are our top picks for the college football Week 10 game between Clemson and Notre Dame (odds via BetMGM, FanDuel Sportsbook, and DraftKings Sportsbook; Pick confidence is based on a 1-to-5-star scale).

Check out our college football best bets and all of our top picks for Week 10.

Clemson vs. Notre Dame Info

Date: Saturday, Nov. 5, 7:30 p.m. ET
TV: NBC/Peacock
Location: Notre Dame Stadium, South Bend, IN
Weather: 64 degrees, 58% chance of precipitation, 25-mph south winds

Clemson vs. Notre Dame Odds

Clemson vs. Notre Dame Odds Analysis

The consensus opening spread had Clemson favored by 3.5 points but that's crept up to -4 as of Saturday morning. There may be some sharp money and big bets on Notre Dame, as 65% of the tickets on the Tigers account for a more modest 59% of the handle.

The Over/Under dropped from an opening line of 49 to 44 despite 57% of the tickets and 52% of the cash being on the Over. Wind is expected to be a factor.

Clemson vs. Notre Dame Picks

Clemson vs. Notre Dame ATS Pick

Notre Dame +4 (-110)

It's hard to argue with most of Clemson's resume, as it ranks fourth in SOR, seventh in FPI, and is the only team in the country with three wins against squads currently ranked in the AP top 25 (Wake Forest, NC State, and Syracuse). However, much of the debate surrounding the Tigers sitting at No. 4 in the initial CFP rankings centered around their 72nd-ranked strength of schedule.

With high winds forecasted in the South Bend area for Saturday, this game could come down to which side gets more of a push up front to control the ground game. The Fighting Irish are enjoying plenty of success running the ball lately while recording 200-plus rushing yards in four of their last five games. Audric Estime has been the catalyst, averaging 5.6 yards per carry. We trust him more than Clemson's Will Shipley, who's facing a Notre Dame defense that holds opponents under four yards per carry.

Be happy to take anything over +3 while backing Notre Dame. BetMGM offers the best value at +4, while all other sportsbooks are a half-point lower at +3.5.

Clemson vs. Notre Dame O/U Pick

Under 44.5 (-110)

Clemson has scored on all but one of its 39 red-zone drives, while Notre Dame has allowed points on 100% of opponents' red-zone possessions. However, the Tigers have scored touchdowns on fewer than 72% of their trips inside the 20-yard line. But Notre Dame's offensive ceiling is limited while up against the nation's seventh-ranked run defense that's allowing 87.9 yards per game.

The Under is 5-1-1 during Clemson's last seven non-conference games, and it's cashed in four of Notre Dame's last five at home. Expect another defensive struggle.

Clemson vs. Notre Dame Prop Pick

Shipley Under 88.5 rushing yards (-115)

Shipley's prop bets will be a popular play because he's the ACC's third-best rusher at 739 yards, and the sophomore is coming off a career-best 172-yard performance against Syracuse.

However, Notre Dame has held opponents under 300 total yards in consecutive weeks, and in three of the team's last four contests. Expect the Fighting Irish to commit more defenders to the box to stop the run, especially with Clemson quarterback D.J. Uiagalelei struggling after being benched in Week 9 following a three-turnover outing.

Where to Bet on Clemson-Notre Dame Picks

Here are our top-rated sportsbooks:

Clemson-Notre Dame picks made 11/4/2022 at 6:18 a.m. ET

Written By:
Mike Spector

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”